I published a supplementary vitamin D the day before yesterday (2022-11-28) and had no effect on the growth and adolescence of childhood. The next day, reader KenSu, left a message in the response column: "I saw a case report before that there...
I published a supplementary vitamin D the day before yesterday (2022-11-28) and had no effect on the growth and adolescence of childhood. The next day, reader KenSu, left a message in the response column:
"I saw a case report before that there was no vitamin D in Pakistan's 60-year-old male who could not experience vitamin D (The article provided by this reader is Very Low Vitamin D in a Patient With a Novel Pathogenic Variant in the GC Gene That Encodes Vitamin D-Binding Protein (a patient with very low vitamin D has a novel pathogenic variant of the vitamin D combined protein gene GC).
The patient is a 60-year-old Pakistani man who has not been able to detect vitamin D for a long time ( or very low). He was first transferred to the endocrinology department at the age of 55 and had a history of vitamin D deficiency for more than 10 years. External records show that he had taken 50,000 vitamin D per week, but his 25(OH) D was still not detected or very low. He said he had also taken calcitriol (that is, the active vitamin D, is a prescription drug), but stopped due to hypercalcemia. He began to suffer from chronic fatigue and low back pain after a car accident, but X-ray examinations showed that his lumbar spine, pelvis, and femur were normal. The storm examination also found no signs of inflammation, dysfunction or stasis. In other words, although he was diagnosed with severe vitamin D deficiency, he did not suffer from vitamin D Deficiencies should cause bone or related diseases.
D is mostly associated with Vitamin D Binding Protein (Vitamin D The binding protein, which is compressed into DBP, forms a synthesis, so the doctor decides to measure the DBP of this patient, and the results show that the DBP level of this patient is extremely low (only 11mcg/ml, with a normal range of 104 to 477). The next gene sequence test found that the GC gene (the gene that expresses DBP) of this patient has a pathogenic change.
At the end of this article, "Our research results support the "homospheric hormone hypothesis". Without circulating DBP, 25(OH)D and 1,25(OH)D are not detected or very low, but the patient maintains normal stability. We agree that those biomarkers that believe that levitra is the more appropriate vitamin D adequacy are ……"
According to the Free Hormone Hypothesis, hormones combined with proteins are inactive, while unbound hormones are free to develop biological activity. However, unfortunately, current vitamins are D Blood tests detect vitamin D combined with protein D. That is to say, the lack or sufficient vitamin D does not have physiological meaning.
Related vitamin The defect of D blood test, I published on 2018-3-13. I quoted two articles: "This research is full of contradictory results. What is the best vitamin D concentration, but has not yet reached a common understanding. …… Current vitamin D measurement The metering method still has high variations, which may lead to incorrect diagnosis of vitamin D deficiency. "
I also published Vitamin D: What is the “ correct ” level?, citing Joel, deputy director of the Bone Density Center of Massachusetts General Hospital "We are currently over-examined vitamin D deficiency and over-treat people who have enough vitamin D through diet and sunshine. Vitamin D has been widely promoted. We do not need to check the vitamin D levels of most healthy people."
I also published the Vitamin D paradox on 2019-12-26, citing two commentaries: "The concentration of serum vitamin D in African Americans is about half of that of white Americans, but the incidence of fractures is only half of that of white Americans. …&hell ip; Based on such results, researchers suggest that the total vitamin D concentration should not be reviewed. "
I published on April 15, 2021 and still couldn't find enough evidence to support the vitamin D screening, pointing out that the US Prevention Services Team (USPSTF) had in 2014. It means there is no sufficient evidence to evaluate the pros and cons of the lack of vitamin D, while the USPSTF's rating in 2021 still cannot find sufficient evidence to evaluate the pros and cons of the vitamin D.
I also issued a decisive judgment on 2022-7-28: Stop taking vitamins D supplements, citing an editorial review from the American Medical Association, said: "Vitamin D does not affect fractures. This should dispel any notion of single use of vitamin D to prevent fractures. These findings, combined with previous VITAL clinical trials, and several other clinical trials, suggest that reviews should be stopped. 25-Radian vitamin D levels or recommended vitamin D supplements. People should stop taking Vitamin D supplements to prevent serious illness or prolong their lives. ”
So, what reader KenSu said, “I think it is unintentional to deduce the vitamin D concentration in the body from here” is consistent with scientific evidence.
Original text: Vitamine D cannot be detected by blood, bones are normal
